LDL cholesterol goal: how low to go in very high-risk patients?

A new meta-analysis shows that very high-risk patients at or below goal gain additional benefit from further LDL cholesterol lowering. This poses key questions for guideline groups: How low should LDL cholesterol goal be set in very high-risk groups? And, how do clinicians identify patients who would benefit most? PCSK9 Forum Editor Professor John Chapman (UPMC-Sorbonne and Director Emeritus, INSERM, Paris, France), gives his view.

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FOURIER update provides new impetus for guideline groups to reconsider LDL targets