VERVE-101 is a single-course base editing agent that targets the
PCSK9 gene in the liver.
read more »
VERVE-102 is a single-course base editing agent that targets the
PCSK9 gene in the liver and uses a different delivery system to VERVE-101.
read more »Enlicitide decanoate (MK-0616) is an oral
PCSK9 inhibitor.
read more »
Bempedoic acid is a small molecule inhibitor of ATP citrate lyase, a key enzyme in cholesterol biosynthesis.
read more »
Inclisiran is a small interfering RNA (siRNA) which limits production of
PCSK9.
read more »
Lerodalcibep (LIB003) is a recombinant fusion protein of a
PCSK9-binding domain (adnectin) and human serum albumin.
read more »
Alirocumab is a fully human monoclonal antibody that binds with high affinity and specificity to
PCSK9 and inhibits its activity.
read more »
Evolocumab is a fully human monoclonal antibody that selectively binds to and inhibits
PCSK9.
read more »Bococizumab is a monoclonal antibody inhibitor of
PCSK9 whose development was terminated in 2016.
read more »
News
