Steve Nicholls Articles
PCSK9 therapeutics – the next story?
Results from a Phase I trial of a new approach to PCSK9 therapeutics, small interfering RNA (siRNA) were presented at ESC Congress 2015. Professor Steve Nicholls, University of Adelaide, Adelaide, Australia discusses the findings and potential clinical implications of this strategy: what would be the…
read more »
How will PCSK9 inhibitors be used in practice?
Professor Steven Nicholls, Professor of Cardiology at the University of Adelaide and the inaugural SAHMRI Heart Foundation Heart Health Theme Leader at the South Australian Health and Medical Research Institute, Australia, discusses the patients in whom these new treatments will be used initially and speculates…
read more »
Does PCSK9 inhibition impact atherosclerosis?
Research shows that progression of atherosclerosis – narrowing of the coronaries due to high density lipoprotein cholesterol (HDL-C) – may be reduced if statins are combined with new PCSK9 inhibitors. This could prevent heart attacks according to one of the trialists, Professor Steve Nicholls from…
read more »
Does PCSK9 inhibition on top of statin therapy offer the possibility of further reducing plaque burden?
Stephen J Nicholls MBBS PhD South Australian Health and Medical Research Institute, University of Adelaide, Australia Technical advances in arterial wall imaging have enabled the visualization of the full burden of atherosclerotic plaque. When applied in serial imaging studies of anatomically matched arterial segments, it…
read more »
