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Bempedoic acid

Bempedoic acid is a small molecule inhibitor of ATP citrate lyase, a key enzyme in cholesterol biosynthesis.

CLEAR Outcomes: Bempedoic acid effects on major CV outcomes (NCT02993406)

CLEAR Outcomes: Bempedoic acid effects on major CV outcomes (NCT02993406)

Study title/design: CLEAR Outcomes: Bempedoic acid effects on major CV outcomes (NCT02993406) Trial NCT02993406 (Completed). Aim To determine if bempedoic acid decreases cardiovascular (CV) events in participants with or at high risk of CV disease who are statin intolerant. Study design Phase 3 randomised, double-blind,…

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CLEAR Harmony Open Label Extension: Long term safety and tolerability of bempedoic acid (NCT03067441)

CLEAR Harmony Open Label Extension: Long term safety and tolerability of bempedoic acid (NCT03067441)

Study title/design: CLEAR Harmony Open Label Extension: Long term safety and tolerability of bempedoic acid (NCT03067441) Trial NCT03067441 (Completed) Aim To determine if bempedoic acid (ETC-1002) is safe and well tolerated in patients at high cardiovascular (CV) risk with elevated LDL-C not adequately controlled by…

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CLEAR Harmony: Long term safety and tolerability of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02666664)

CLEAR Harmony: Long term safety and tolerability of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02666664)

Study title/design: CLEAR Harmony: Long term safety and tolerability of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02666664) Trial NCT02666664 (Completed). Aim To determine if bempedoic acid (ETC-1002) is safe and well tolerated in patients at high cardiovascular (CV) risk with elevated…

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CLEAR Wisdom: Long term efficacy of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02991118)

CLEAR Wisdom: Long term efficacy of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02991118)

Study title/design: CLEAR Wisdom: Long term efficacy of bempedoic acid in patients with hyperlipidaemia and high CV risk (NCT02991118) Trial NCT0299118 (Completed). Aim To determine if bempedoic acid (ETC-1002) is effective in patients at high cardiovascular (CV) risk with elevated LDL-C not adequately controlled by…

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CLEAR Serenity: Bempedoic acid in patients with hyperlipidaemia and statin intolerance (NCT02988115)

CLEAR Serenity: Bempedoic acid in patients with hyperlipidaemia and statin intolerance (NCT02988115)

Study title/design: CLEAR Serenity: Bempedoic acid in patients with hyperlipidaemia and statin intolerance (NCT02988115) Trial NCT02988115 (Completed). Aim To determine if bempedoic acid (ETC-1002) is effective and safe in patients with elevated LDL-C who are statin intolerant. Study design Phase 3 randomised, double-blind, placebo-controlled study…

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