Unmet Needs
Unmet clinical needs in cholesterol lowering
A high level of low-density lipoprotein (LDL) cholesterol, or ‘bad cholesterol’, is considered a major modifiable risk factor for cardiovascular disease. International guidelines state that lowering LDL cholesterol is one of most important interventions in reducing the risk of premature cardiovascular events.1-4 New insights from…
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PCSK9 inhibition: a role in treating sepsis?
Microbial cell walls contain pathogen lipids, such as lipopolysaccharide, which not only act as ligands for innate immune receptors, but also trigger the inflammatory response during sepsis (1). These pathogen lipids are mainly cleared by hepatic uptake, a process which also involves the low-density lipoprotein…
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LDL treatment choices in everyday practice too conservative
Results from a survey of more than 1,500 patients showed that physicians are too cautious in managing low-density lipoprotein (LDL) cholesterol in high cardiovascular risk patients, even when they are not at goal. The findings are particularly relevant in the light of recent favourable opinions…
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High cholesterol: an unmet need
Health authorities are failing to recognise that most patients do not achieve the cholesterol levels needed to prevent cardiovascular disease. Professor Lluís Masana says this must become a public health priority.
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Unmet clinical needs in cholesterol lowering
Recent decades has seen marked improvement in reducing rates of heart disease and stroke (cardiovascular disease), particularly in developed nations.1 High levels of low-density lipoprotein cholesterol (LDL-C), or ‘bad cholesterol’ are considered a major risk factor for cardiovascular disease. International guidelines state that reduction of…
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